WEBVTT 00:00:00.000 --> 00:00:04.030 align:middle line:90% 00:00:04.030 --> 00:00:07.420 align:middle line:84% So the short-term shutoff in response to PA 00:00:07.420 --> 00:00:10.450 align:middle line:84% is that it protects the insects from over ingestion of them. 00:00:10.450 --> 00:00:13.300 align:middle line:84% Now, they're toxic, and these insects 00:00:13.300 --> 00:00:15.070 align:middle line:90% are adapted to deal with them. 00:00:15.070 --> 00:00:18.460 align:middle line:84% But we thought that it could be that they get too much of it, 00:00:18.460 --> 00:00:21.920 align:middle line:84% and too much of a good thing can also be toxic to them. 00:00:21.920 --> 00:00:25.900 align:middle line:84% In fact, we've reared them on diet with these PAs in, 00:00:25.900 --> 00:00:27.390 align:middle line:90% and it's not true. 00:00:27.390 --> 00:00:29.510 align:middle line:90% They can take any amount. 00:00:29.510 --> 00:00:32.420 align:middle line:90% So this is not an issue. 00:00:32.420 --> 00:00:34.450 align:middle line:84% But it does ensure that the insects retain 00:00:34.450 --> 00:00:37.630 align:middle line:84% their normal food-mixing habit, and that's 00:00:37.630 --> 00:00:41.170 align:middle line:84% needed to prevent over-ingestion of all the other toxins. 00:00:41.170 --> 00:00:43.600 align:middle line:90% Now, even these PA plants-- 00:00:43.600 --> 00:00:45.610 align:middle line:84% they have the chemical they need, 00:00:45.610 --> 00:00:48.470 align:middle line:84% but they've got other stuff in them too which is bad. 00:00:48.470 --> 00:00:49.870 align:middle line:90% So here's your problem. 00:00:49.870 --> 00:00:51.462 align:middle line:84% You've got to get the PAs, but you 00:00:51.462 --> 00:00:53.170 align:middle line:84% don't want to eat too much of that plant, 00:00:53.170 --> 00:00:56.390 align:middle line:84% because there's all kinds of other bad stuff there. 00:00:56.390 --> 00:01:00.550 align:middle line:84% And so, what we believe is that shutting off the PA cell 00:01:00.550 --> 00:01:04.000 align:middle line:84% means that they stop eating that PA plant for a while. 00:01:04.000 --> 00:01:06.310 align:middle line:84% Not because of the PAs, but because 00:01:06.310 --> 00:01:08.500 align:middle line:84% of all this other stuff in there. 00:01:08.500 --> 00:01:09.000 align:middle line:90%